Short Description Physician‑scientist demonstrating calorie‑restriction benefits in humans.
Description Dr. Luigi Fontana is a dual‑appointed professor at the University of Sydney and Washington University in St. Louis. He runs the longest‑running cohort study of humans practicing chronic calorie restriction, revealing profound cardiometabolic and inflammatory improvements without malnutrition. Fontana’s mechanistic work links amino‑acid restriction to lowered mTOR activity, IGF‑1 signaling, and reduced DNA damage in both rodents and humans. He authored ‘The Path to Longevity’ and consults for the WHO on dietary guidelines aimed at extending healthy lifespan worldwide.
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