Short Description Mayo Clinic scientist linking mitochondrial fission to senescence.
Description Portuguese biologist João Passos discovered that dysfunctional mitochondria trigger the senescence‑associated secretory phenotype (SASP) via cytosolic mtDNA. He revealed that targeting Drp1‑mediated fission alleviates SASP in aged stem cells, suggesting novel senostatic strategies. Passos collaborates with Unity Biotechnology and lectures at Cold Spring Harbor courses on cellular aging.